Cancer cells are known to favor aerobic glycolysis for energy production, a phenomenon termed the Warburg effect. This metabolic shift is essential for tumor growth, supplying energy, metabolites, and maintaining redox balance. The pyruvate dehydrogenase complex (PDC) plays a pivotal role in linking glycolysis to the tricarboxylic acid (TCA) cycle, but the mechanisms regulating PDC activity—especially through post-translational modifications like acetylation—remain poorly understood. While previous research has focused on the phosphorylation of pyruvate dehydrogenase (PDH), acetylation has been largely overlooked, making it a critical area for further exploration. In a study (DOI: 10.1093/procel/pwae052) published on September 23, 2024, in Protein...